Department of Orthopedic Surgery, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea.
Expert Rev Anticancer Ther. 2010 Aug;10(8):1313-25. doi: 10.1586/era.10.79.
Despite numerous chemotherapy trials and the introduction of novel agents, survival in localized osteosarcoma, which plateaued in the mid-1980s, has been recalcitrant to our best efforts. The authors considered that a review of previous and current strategies that target survival might provide a direction for research efforts. Here, the focus is placed mainly on the reappraisal of previous mass chemotherapy trials and prognostic factors, in the hope of contriving a strategy to overcome the current stasis.
尽管进行了大量的化疗试验和新型药物的引入，但局部骨肉瘤的生存率（自 20 世纪 80 年代中期以来已趋于稳定）一直难以提高，这是我们最大努力的结果。作者认为，对以前和当前针对生存的策略进行回顾，可能为研究工作提供一个方向。在这里，主要重点是重新评估以前的大规模化疗试验和预后因素，希望能设计出一种策略来克服当前的僵局。
