Mori N, Hoshino S, Kumashiro H
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Brain Res. 1990 Nov 26;534(1-2):329-31. doi: 10.1016/0006-8993(90)90151-z.
Kindling was induced in rats by electrical stimulation of the lateral portion of the substantia innominata (SI). The pattern of seizure development was similar to that of amygdala (AM) kindling. However, lateral SI kindling was associated with ipsilateral head turning as an initial manifestation. In addition, lateral SI kindling had a higher afterdischarge threshold than AM kindling, and the generalized seizure triggering threshold was more unstable in SI kindling than in AM kindling. These findings suggest that lateral SI participates in, but is not essential for, AM seizure development in rats.
通过电刺激无名质（SI）外侧部分在大鼠中诱发点燃效应。癫痫发作发展模式与杏仁核（AM）点燃效应相似。然而，SI外侧点燃效应最初表现为同侧头部转动。此外，SI外侧点燃效应的后放电阈值高于AM点燃效应，并且SI点燃效应中全身癫痫发作触发阈值比AM点燃效应更不稳定。这些发现表明，SI外侧参与了大鼠AM癫痫发作的发展，但并非必不可少。
