Unidad de Insuficiencia Cardiaca, Departamento de Medicina, Universidad Autónoma de Barcelona, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España.
Rev Esp Cardiol. 2010 Aug;63(8):992-6. doi: 10.1016/s1885-5857(10)70194-8.
Muscle wasting is common in advanced heart failure. Myostatin is an important modulator of muscle catabolism. We measured serum levels of myostatin and its propeptide in patients with chronic heart failure and analyzed their relationships with clinical parameters and prognosis. The study included 70 patients: 30 in New York Heart Association (NYHA) functional class I-II and 40 in class III-IV. Their mean ejection fraction was 32%+/-12%. The mean follow-up time was 17.9+/-1.3 months. Thirteen patients (18.6%) died. No correlation was found between myostatin and myostatin propeptide levels. Nor was the myostatin or myostatin propeptide level correlated with age, sex, left ventricular ejection fraction, symptom duration, or the level of N-terminal probrain natriuretic peptide (NT-proBNP) or tumor necrosis factor-alpha receptor type-2 (TNFalpha R2). Moreover, no relationship was observed between the myostatin or myostatin propeptide level and NYHA functional class or mortality, in contrast to the relationships found with NT-proBNP (P< .001 and P< .001, respectively) and TNFalpha R2 (P=.001 and P=.005, respectively) levels. In conclusion, there was no relationship between the myostatin or myostatin propeptide level and any parameter of disease severity or prognosis in patients with chronic heart failure.
肌肉减少症在晚期心力衰竭中很常见。肌肉生长抑制素是肌肉分解代谢的重要调节剂。我们测量了慢性心力衰竭患者的血清肌肉生长抑制素及其前肽水平，并分析了它们与临床参数和预后的关系。该研究包括 70 例患者：30 例纽约心脏协会（NYHA）心功能 I-II 级，40 例心功能 III-IV 级。他们的平均射血分数为 32%+/-12%。平均随访时间为 17.9+/-1.3 个月。13 例患者（18.6%）死亡。肌肉生长抑制素和肌肉生长抑制素前肽水平之间没有相关性。肌肉生长抑制素或肌肉生长抑制素前肽水平与年龄、性别、左心室射血分数、症状持续时间或 N 末端脑利钠肽前体（NT-proBNP）或肿瘤坏死因子-α受体 2（TNFalpha R2）水平也没有相关性。此外，与 NT-proBNP（分别为 P<.001 和 P<.001）和 TNFalpha R2（分别为 P=.001 和 P=.005）水平相比，肌肉生长抑制素或肌肉生长抑制素前肽水平与 NYHA 心功能分级或死亡率之间没有关系。总之，在慢性心力衰竭患者中，肌肉生长抑制素或肌肉生长抑制素前肽水平与任何疾病严重程度或预后参数之间均无关系。
