Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrechts-Universität zu Kiel, Arnold-Heller-Str. 3, Haus 26, 24105 Kiel, Germany.
J Dent Res. 2010 Nov;89(11):1276-80. doi: 10.1177/0022034510376040. Epub 2010 Aug 25.
To define the optimized material properties of caries-infiltrating resins (infiltrants), we evaluated the effects of infiltrant composition and penetration coefficient (PC) on the inhibition of the progression of natural approximal caries lesions in vitro. Non-cavitated natural enamel lesions were etched (15% HCl gel) and infiltrated for 5 min with experimental resins varying in PC (cm/sec): PC63, PC185, PC204, and PC391. As a positive control (PosC), lesions were covered with flowable composite resin, whereas untreated lesions served as negative controls (NegC). Specimens were exposed to a demineralizing solution (pH 4.95) for 400 days. Progression of mineral loss was analyzed by transverse wavelength-independent microradiography. Percentage progressions of NegC [median (25th/75th percentile), 24 (10/56)], PC63 [9 (3/39)], and PC185 [12 (9/24)] were significantly higher compared with those of PosC [1 (-8/8)], PC204 [-2 (-4/2)], and PC391 [0 (-5/9)] (p < 0.05). Thus, infiltrants with PC > 200 cm/sec are capable of inhibiting lesion progression.
为了确定龋浸树脂（渗透剂）的最佳材料特性，我们评估了渗透剂组成和渗透系数（PC）对体外自然邻面龋损进展的抑制作用。非窝洞性自然釉质病损用 15%盐酸凝胶蚀刻（etch）15% HCl gel）并渗透 5 分钟，用 PC 不同的实验性树脂（cm/sec）进行渗透：PC63、PC185、PC204 和 PC391。作为阳性对照（PosC），用流动复合树脂覆盖病损，而未处理的病损作为阴性对照（NegC）。标本在脱矿溶液（pH 4.95）中暴露 400 天。用横向无波长依赖的显微放射摄影术分析矿物质损失的进展情况。NegC 的进展百分比[中位数（25/75 分位数），24（10/56）]、PC63 [9（3/39）]和 PC185 [12（9/24）]明显高于 PosC [1（-8/8）]、PC204 [-2（-4/2）]和 PC391 [-2（-5/9）]（p < 0.05）。因此，PC>200 cm/sec 的渗透剂能够抑制病变进展。
