Cooperative Research Centre for Oral Health Science, Melbourne Dental School, Bi021 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3000, Australia.
J Dent Res. 2010 Nov;89(11):1187-97. doi: 10.1177/0022034510376046. Epub 2010 Aug 25.
Dental caries is a highly prevalent diet-related disease and is a major public health problem. A goal of modern dentistry is to manage non-cavitated caries lesions non-invasively through remineralization in an attempt to prevent disease progression and improve aesthetics, strength, and function. Remineralization is defined as the process whereby calcium and phosphate ions are supplied from a source external to the tooth to promote ion deposition into crystal voids in demineralized enamel, to produce net mineral gain. Recently, a range of novel calcium-phosphate-based remineralization delivery systems has been developed for clinical application. These delivery systems include crystalline, unstabilized amorphous, or stabilized amorphous formulations of calcium phosphate. These systems are reviewed, and the technology with the most scientific evidence to support its clinical use is the remineralizing system utilizing casein phosphopeptides to stabilize and deliver bioavailable calcium, phosphate, and fluoride ions. The recent clinical evidence for this technology is presented and the mechanism of action discussed. Biomimetic approaches to stabilization of bioavailable calcium, phosphate, and fluoride ions and the localization of these ions to non-cavitated caries lesions for controlled remineralization show promise for the non-invasive management of dental caries.
龋齿是一种高发的与饮食相关的疾病，也是一个主要的公共卫生问题。现代牙科的目标是通过再矿化来非侵入性地治疗非龋性病变，试图预防疾病进展并改善美观、强度和功能。再矿化是指钙和磷酸盐离子从牙齿外部的来源供应，以促进离子沉积到脱矿釉质的晶体空隙中，从而产生净矿物质增加的过程。最近，已经开发出一系列新型的基于钙磷的再矿化输送系统用于临床应用。这些输送系统包括结晶、非稳定的无定形或稳定的无定形的磷酸钙制剂。本文对这些系统进行了综述，具有最多科学证据支持其临床应用的技术是利用酪蛋白磷酸肽稳定和输送生物可利用的钙、磷和氟离子的再矿化系统。本文介绍了该技术的最新临床证据，并讨论了其作用机制。生物仿生方法稳定生物可利用的钙、磷和氟离子，并将这些离子定位到非龋性病变部位以进行控制再矿化，为非侵入性治疗龋齿提供了希望。
