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非氟再矿化技术的最新进展。

Latest developments in non-fluoridated remineralizing technologies.

作者信息

Goswami M, Saha S, Chaitra T R

机构信息

Department of Pediatric and Preventive Dentistry, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India.

出版信息

J Indian Soc Pedod Prev Dent. 2012 Jan-Mar;30(1):2-6. doi: 10.4103/0970-4388.95561.

DOI:10.4103/0970-4388.95561
PMID:22565510
Abstract

The goal of modern dentistry is to manage non-cavitated carious lesions non-invasively through remineralization in an attempt to prevent disease progression, and to improve strength, esthetics, and function of teeth. The emphasis currently is being given to new technologies for enamel remineralization which suggest the changes in the understanding of dental caries. The aim of this paper is to review the contemporary non-fluoridated systems available for remineralization therapy and ideas for their implementation into clinical practice. A search of articles from "Pubmed" and "Medline" with the keywords Remineralization-demineralization, Casein derivatives, Non-fluoridated remineralizing agents was conducted. A total of 526 abstracts were collected, out of which 172 articles that discussed current technologies of non-fluoridated remineralizing agents were read and 33 most relevant articles were included in this paper. Casein phosphopeptide based technology has been established as a strong non-fluoridated remineralizing agent fulfilling all the criteria of an ideal remineralizing material.

摘要

现代牙科的目标是通过再矿化以非侵入性方式处理非龋洞性龋损,试图预防疾病进展,并改善牙齿的强度、美观和功能。目前重点关注牙釉质再矿化的新技术,这表明对龋齿的认识发生了变化。本文的目的是综述当前可用于再矿化治疗的非氟化系统及其在临床实践中的应用思路。通过在“Pubmed”和“Medline”上搜索关键词为“再矿化-脱矿化”、“酪蛋白衍生物”、“非氟化再矿化剂”的文章。共收集了526篇摘要,其中阅读了172篇讨论非氟化再矿化剂当前技术的文章,并将33篇最相关的文章纳入本文。基于酪蛋白磷酸肽的技术已被确立为一种强大的非氟化再矿化剂,满足理想再矿化材料的所有标准。

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1
Latest developments in non-fluoridated remineralizing technologies.非氟再矿化技术的最新进展。
J Indian Soc Pedod Prev Dent. 2012 Jan-Mar;30(1):2-6. doi: 10.4103/0970-4388.95561.
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New approaches to enhanced remineralization of tooth enamel.增强牙釉质再矿化的新方法。
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Anticariogenicity of casein phosphopeptide-amorphous calcium phosphate: a review of the literature.酪蛋白磷酸肽-无定形磷酸钙的防龋性:文献综述
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引用本文的文献

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Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges.牙釉质修复与再生的下一代策略:生物材料的进展与转化挑战
Tissue Eng Regen Med. 2025 May 10. doi: 10.1007/s13770-025-00725-w.
2
Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions.再矿化剂的系统评价与Meta分析:对白斑病变的疗效
Bioengineering (Basel). 2025 Jan 20;12(1):93. doi: 10.3390/bioengineering12010093.
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Effect of Biomin F toothpaste and Diode laser on remineralization of white spot lesions (in vitro study).
生物酶牙膏和半导体激光对釉质白斑再矿化的影响(体外研究)。
BMC Oral Health. 2024 Jul 30;24(1):866. doi: 10.1186/s12903-024-04589-9.
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Recent Advances in Caries Prevention-An Update.龋病预防的最新进展——最新情况
J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S35-S37. doi: 10.4103/jpbs.jpbs_705_23. Epub 2023 Nov 7.
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Comparative Evaluation of the Remineralizing Potential of Silver Diamine Fluoride, Casein Phosphopeptide-amorphous Calcium Phosphate, and Fluoride Varnish on the Enamel Surface of Primary and Permanent Teeth: An Study.氟化亚锡、酪蛋白磷酸肽-无定形磷酸钙和氟化物清漆对乳牙和恒牙牙釉质表面再矿化潜力的比较评估:一项研究。
Int J Clin Pediatr Dent. 2023 Aug;16(Suppl 1):S91-S96. doi: 10.5005/jp-journals-10005-2622.
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Comparison of Remineralization Potential of Casein Phosphopeptide: Amorphous Calcium Phosphate, Nano-hydroxyapatite and Calcium Sucrose Phosphate on Artificial Enamel Lesions: An Study.酪蛋白磷酸肽:无定形磷酸钙、纳米羟基磷灰石和蔗糖磷酸钙对人工釉质病变再矿化潜力的比较:一项研究。
Int J Clin Pediatr Dent. 2022 Jan-Feb;15(1):69-73. doi: 10.5005/jp-journals-10005-2339.
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Is there evidence for Novamin application in remineralization?: A Systematic review.诺瓦敏用于再矿化是否有证据支持?一项系统评价。
J Oral Biol Craniofac Res. 2020 Apr-Jun;10(2):87-92. doi: 10.1016/j.jobcr.2020.01.001. Epub 2020 Jan 22.
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Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: An study.仿生自组装肽对人工诱导釉质病变再矿化效果的比较评价:一项研究。
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