Gloria Antonio, Russo Teresa, De Santis Roberto, Ambrosio Luigi
Institute of Composite and Biomedical Materials, National Research Council, Naples - Italy.
J Appl Biomater Biomech. 2009 Sep-Dec;7(3):141-52.
Tissue engineering represents an interesting approach which aims to create tissues and organs de novo. In designing scaffolds for tissue engineering applications, the principal goal is to mimic the function of the natural extracellular matrix, providing a temporary template for the growth of target tissues. For this reason, scaffolds should possess suitable mechanical properties and architecture to play their specific role. In this paper, limitations of conventional scaffold fabrication methods will be briefly introduced, and rapid prototyping techniques will be described as advanced processing methods to realize customized scaffolds with controlled internal microarchitecture. Among the rapid prototyping techniques, the potential and challenges of 3D fiber deposition to create multifunctional and tailor-made scaffolds will be reviewed.
组织工程是一种旨在从头创建组织和器官的有趣方法。在设计用于组织工程应用的支架时，主要目标是模拟天然细胞外基质的功能，为目标组织的生长提供临时模板。因此，支架应具备合适的机械性能和结构以发挥其特定作用。本文将简要介绍传统支架制造方法的局限性，并将快速成型技术描述为实现具有可控内部微结构的定制支架的先进加工方法。在快速成型技术中，将对用于创建多功能和量身定制支架的三维纤维沉积的潜力和挑战进行综述。
