Yeong Wai-Yee, Chua Chee-Kai, Leong Kah-Fai, Chandrasekaran Margam
Rapid Prototyping Research Laboratory, Design Research Centre, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore 639798.
Trends Biotechnol. 2004 Dec;22(12):643-52. doi: 10.1016/j.tibtech.2004.10.004.
Tissue engineering aims to produce patient-specific biological substitutes in an attempt to circumvent the limitations of existing clinical treatments for damaged tissue or organs. The main regenerative tissue engineering approach involves transplantation of cells onto scaffolds. The scaffold attempts to mimic the function of the natural extracellular matrix, providing a temporary template for the growth of target tissues. Scaffolds should have suitable architecture and strength to serve their intended function. This paper presents a comprehensive review of the fabrication methods, including conventional, mainly manual, techniques and advanced processing methods such as rapid prototyping (RP) techniques. The potential and challenges of scaffold-based technology are discussed from the perspective of RP technology.
组织工程旨在制造针对患者的生物替代物，以克服现有受损组织或器官临床治疗方法的局限性。主要的再生组织工程方法包括将细胞移植到支架上。支架试图模拟天然细胞外基质的功能，为目标组织的生长提供临时模板。支架应具备合适的结构和强度以发挥其预期功能。本文全面综述了制造方法，包括传统的（主要是手工的）技术以及先进的加工方法，如快速成型（RP）技术。从RP技术的角度讨论了基于支架技术的潜力和挑战。
