Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea.
J Surg Oncol. 2010 Sep 1;102(3):201-6. doi: 10.1002/jso.21583.
We designed this study to assess the biologic significance of Ki-67 proliferation index (PI) in gastric cancer.
Gastric cancer tissue from 245 patients were immunostained for Ki-67. Ki-67 PI was defined as the percentage of tumor cells positive for Ki-67. In addition, we have previously evaluated the expressions of nine epithelial mesenchymal transition (EMT)-related proteins. The relationship between Ki-67 PI and clinicopathologic parameters, patient survival, and EMT data were sought.
Low Ki-67 PI was correlated with poorly differentiated histology (P = 0.034), an advanced T stage (P < 0.001), and lymph node metastasis (P = 0.011). Also, the low PI group was found to have a significantly worse prognosis than the high PI group (P = 0.003, log-rank test). Multivariate analysis revealed that Ki-67 PI remained as an independent prognostic factor (hazard ratio (95% CI) = 0.670 (0.450-0.999)). Furthermore, greater expressional changes of EMT-related proteins were found to be significantly associated with low Ki-67 PI (P = 0.025).
These findings suggest that Ki-67 PI is an effective tool for predicting survival in gastric cancer. In addition, we found that an invasive property presented as EMT-related protein expressional changes was inversely correlated with a proliferative activity in gastric cancer.
我们设计本研究旨在评估 Ki-67 增殖指数（PI）在胃癌中的生物学意义。
对 245 例胃癌组织进行 Ki-67 免疫组化染色。Ki-67 PI 定义为 Ki-67 阳性肿瘤细胞的百分比。此外，我们之前还评估了九种上皮间质转化（EMT）相关蛋白的表达。寻求 Ki-67 PI 与临床病理参数、患者生存和 EMT 数据之间的关系。
低 Ki-67 PI 与组织学低分化（P = 0.034）、T 期较晚（P < 0.001）和淋巴结转移（P = 0.011）相关。此外，低 PI 组的预后明显比高 PI 组差（P = 0.003，对数秩检验）。多因素分析显示 Ki-67 PI 仍然是独立的预后因素（风险比（95%CI）= 0.670（0.450-0.999））。此外，发现 EMT 相关蛋白的表达变化越大，与低 Ki-67 PI 显著相关（P = 0.025）。
这些发现表明 Ki-67 PI 是预测胃癌患者生存的有效工具。此外，我们发现侵袭性表型呈 EMT 相关蛋白表达变化与胃癌的增殖活性呈负相关。
