University of Medicine and Pharmacy Carol Davila, Department of Clinical Pharmacology and Toxicology, Bucharest, Romania.
J Pharm Sci. 2011 Feb;100(2):704-14. doi: 10.1002/jps.22308. Epub 2010 Aug 25.
In the present study, captopril-loaded ordered mesoporous SBA-15 silica matrix were produced, functionalized, and characterized to obtain an efficient formulation of controlled drug delivery system. First, the starting SBA-15 materials are examined to verify that their synthesis has been successful considering the structural properties, using XRD, FTIR, and BET methods. Second, the influence of processing parameters of ordered mesoporous matrices for the loading and release of captopril was investigated. The release of captopril was controlled by tailoring the surface properties of the mesoporous silica via functionalization. The loading and release kinetics (in vitro in simulated gastric and intestinal fluids) showed that both of them were affected by the surface properties of the mesoporous silica materials. Such a formulation shows potential as an efficient controlled drug delivery system.
在本研究中，制备了载有卡托普利的有序介孔 SBA-15 硅基质，并对其进行了功能化和表征，以获得一种有效的控制药物释放系统的制剂。首先，使用 XRD、FTIR 和 BET 方法检查起始 SBA-15 材料，以验证其合成在结构特性方面是否成功。其次，研究了有序介孔基质的加工参数对卡托普利的负载和释放的影响。通过对介孔硅的表面性质进行功能化，可以控制卡托普利的释放。负载和释放动力学（在模拟胃液和肠液中的体外）表明，两者都受到介孔硅材料表面性质的影响。这种制剂具有作为一种有效的控制药物释放系统的潜力。
