Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Qld., Australia.
Psychooncology. 2011 Nov;20(11):1161-9. doi: 10.1002/pon.1834. Epub 2010 Aug 26.
To document levels of and changes in physical activity before and after ovarian cancer diagnosis and explore associations with psychosocial outcomes.
Of 1207 eligible Australian Ovarian Cancer Study (AOCS) participants, 798 participated in an additional prospective Quality of Life (QoL) Study which measured anxiety, depression and QoL at 3-6 monthly intervals for 2 years beginning 3-48 months after diagnosis. AOCS asked about physical activity before diagnosis and 530 women also completed a one-off lifestyle questionnaire 7-64 months after diagnosis which assessed activity during their first and, if relevant, second-to-third and fourth-to-sixth years following diagnosis. Analysis of variance was used to relate physical activity to psychosocial outcomes.
Almost 40% of women decreased their physical activity in the first year after diagnosis. Approximately 25% still had lower levels after 2-3 and 4+years. Recent physical activity level was inversely associated with depression and positively associated with QoL (P<0.05). Also, women who maintained or increased their physical activity after diagnosis had better mean depression and QoL scores than women who decreased physical activity or remained inactive (P<0.05). Among women who received chemotherapy shortly prior to completing the lifestyle questionnaire, high versus low or medium physical activity was associated with significantly lower mean depression scores during both periods of treatment and non-treatment (P<0.05).
Many women did not regain their pre-morbid physical activity levels several years after ovarian cancer diagnosis. Low physical activity may simply be a consequence of poor well-being but, alternatively, physical activity may improve psychosocial health of this group.
记录卵巢癌诊断前后体力活动的水平和变化，并探讨其与心理社会结局的关系。
在 1207 名符合条件的澳大利亚卵巢癌研究（AOCS）参与者中，798 名参与者参加了一项额外的前瞻性生活质量（QoL）研究，该研究在诊断后 3-48 个月开始的 2 年内，每 3-6 个月测量一次焦虑、抑郁和 QoL。AOCS 在诊断前询问了参与者的体力活动情况，而 530 名女性还在诊断后 7-64 个月完成了一次性生活方式问卷，该问卷评估了她们在诊断后的第一年内、如果相关的话，第二至第三年和第四至第六年内的活动情况。方差分析用于将体力活动与心理社会结局相关联。
近 40%的女性在诊断后第一年减少了体力活动。大约 25%的女性在 2-3 年和 4 年以上后体力活动水平仍然较低。最近的体力活动水平与抑郁呈负相关，与 QoL 呈正相关（P<0.05）。此外，与减少体力活动或保持不活动的女性相比，在诊断后保持或增加体力活动的女性抑郁和 QoL 评分的平均值更好（P<0.05）。在生活方式问卷完成前不久接受化疗的女性中，高体力活动与治疗和非治疗期间的平均抑郁评分显著降低相关（P<0.05）。
许多女性在卵巢癌诊断后数年仍未恢复到患病前的体力活动水平。低体力活动可能仅仅是健康状况不佳的结果，但另一方面，体力活动可能会改善这一群体的心理社会健康。
