Todaro G J, Benveniste R E, Sherwin S A, Sherr C J
Cell. 1978 Apr;13(4):775-82. doi: 10.1016/0092-8674(78)90227-1.
A new class of endogenous primate type C virus has been isolated from a continuous tissue culture line of Macaca arctoides cells by co-cultivation with a human cell line. The virus, designated MAC-1, can be transmitted to human and feline cells in tissue culture, and is unrelated, by immunological and nucleic acid hybridization criteria, to previously characterized retroviral isolates of primates. In particular, MAC-1 shows no detectable homology to the baboon type C viruses, even though viral genes related to the latter group are readily detected in M. arctoides cellular DNA. Viral gene sequences related to the MAC-1 genome are present in multiple copies (50-150 per haploid genome) in Old World primates, and are expressed in the cellular RNAs of uninfected and "virus-free" primate cells and tissues. Thus there are at least two distinct sets of genetically transmitted Old World primate type C viral genes, each of which is found in multiple copies in normal primate cellular DNA. With the description of this new retrovirus, there are now a minimum of five distinct genetically transmitted viruses of primates, three type C and type D, each represented in multiple copies in the normal cellular DNA.
通过与一种人类细胞系共同培养，从一种熊猴细胞的连续组织培养系中分离出了一类新的内源性灵长类C型病毒。该病毒被命名为MAC-1，在组织培养中可传播至人类和猫科动物细胞，根据免疫学和核酸杂交标准，它与先前鉴定的灵长类逆转录病毒分离株无关。特别是，MAC-1与狒狒C型病毒没有可检测到的同源性，尽管在熊猴细胞DNA中很容易检测到与后一组相关的病毒基因。与MAC-1基因组相关的病毒基因序列在旧世界灵长类动物中以多拷贝形式存在（每个单倍体基因组有50-150个拷贝），并在未感染和“无病毒”的灵长类动物细胞及组织的细胞RNA中表达。因此，至少有两组不同的通过基因传递的旧世界灵长类C型病毒基因，每组在正常灵长类动物细胞DNA中都以多拷贝形式存在。随着这种新逆转录病毒的描述，现在至少有五种不同的通过基因传递的灵长类病毒，三种C型和D型，每种在正常细胞DNA中都以多拷贝形式存在。
