Sarai M, Matsunaga H, Kimura S
Kosaka Hospital, Osaka, Japan.
Jpn J Psychiatry Neurol. 1990 Sep;44(3):557-62. doi: 10.1111/j.1440-1819.1990.tb01629.x.
The authors studied the concentrations of plasma catecholamines in 23 acute schizophrenics, 28 healthy controls, 20 chronic schizophrenics, and 26 otherwise diagnosed psychiatric cases. Blood samples were taken from the consecutively admitted acute schizophrenics before the administration of antipsychotic drugs and catecholamines were assayed with a high performance liquid chromatography and electrochemical detector. Plasma adrenaline in the acute schizophrenics and the other psychiatric patients was significantly elevated in comparison with the healthy controls. There were no significant differences in the noradrenaline concentrations among the four groups. The plasma dopamine concentrations in the acute schizophrenics were also higher than those in the healthy controls. It is unlikely that physical exercise caused the elevation of dopamine in the acute schizophrenics. There was no significant correlation between plasma catecholamines and BPRS scores in the acute schizophrenics.
作者研究了23例急性精神分裂症患者、28例健康对照者、20例慢性精神分裂症患者以及26例其他诊断的精神病例的血浆儿茶酚胺浓度。在抗精神病药物给药前，从连续入院的急性精神分裂症患者中采集血样，并用高效液相色谱和电化学检测器测定儿茶酚胺。与健康对照者相比，急性精神分裂症患者和其他精神疾病患者的血浆肾上腺素显著升高。四组间去甲肾上腺素浓度无显著差异。急性精神分裂症患者的血浆多巴胺浓度也高于健康对照者。体育锻炼不太可能导致急性精神分裂症患者多巴胺升高。急性精神分裂症患者的血浆儿茶酚胺与简明精神病评定量表（BPRS）评分之间无显著相关性。
