促肾上腺皮质激素长期治疗对大鼠肾上腺皮质细胞内环磷酸腺苷和环磷酸鸟苷水平的影响。
Effects of chronic treatment with ACTH on the intracellular levels of cyclic-AMP and cyclic-GMP in the rat adrenal cortex.
作者信息
Neri G, Gambino A M, Mazzocchi G, Nussdorfer G G
出版信息
Experientia. 1978 Jun 15;34(6):815-7. doi: 10.1007/BF01947346.
PMID:207562
Abstract
The effects of chronic ACTH treatment on the increase in the intracellular concentration of cyclic-AMP and cyclic-GMP acutely elicited by ACTH in the rat adrenal cortex were investigated. The results are consistent with the hypothesis that chronic ACTH treatment stimulates a) the de novo synthesis of adenylate- and guanylate-cyclase or b) the synthesis of new specific membrane receptors for ACTH.
摘要
研究了慢性促肾上腺皮质激素（ACTH）处理对大鼠肾上腺皮质中由ACTH急性引发的环磷酸腺苷（cyclic-AMP）和环磷酸鸟苷（cyclic-GMP）细胞内浓度增加的影响。结果与以下假设一致：慢性ACTH处理刺激了a）腺苷酸环化酶和鸟苷酸环化酶的从头合成，或b）ACTH新的特异性膜受体的合成。
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