Zieleniewski J, Nowakowska-Jankiewicz B, Stepień H, Zieleniewski W
Clinic of Endocrinology, Academy of Medicine, Lódź, Poland.
Cytobios. 1990;64(257):81-5.
The effect of diazepam on adrenocortical cell proliferation was investigated in unilaterally adrenalectomized Wistar rats by evaluation of the mitotic ratio. Diazepam administration (5 mg/kg/day) was shown to decrease the mitotic index of the adrenal cortex on the 5th day after monoadrenalectomy, while on the 10th day after the operation the inhibitory effect became insignificant. The possible mechanism of diazepam action is discussed.
通过评估有丝分裂比率，研究了地西泮对单侧肾上腺切除的Wistar大鼠肾上腺皮质细胞增殖的影响。结果显示，给予地西泮（5毫克/千克/天）可使单侧肾上腺切除术后第5天肾上腺皮质的有丝分裂指数降低，而在术后第10天，这种抑制作用变得不明显。本文讨论了地西泮作用的可能机制。
