体外灌注早产和足月分娩的脐动脉中前列腺素的产生。

Prostanoid production in umbilical arteries from preterm and term deliveries perfused in vitro.

作者信息

Haugen G, Stray-Pedersen S, Bjøro K

机构信息

Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.

出版信息

Early Hum Dev. 1990 Nov;24(2):153-61. doi: 10.1016/0378-3782(90)90144-8.

DOI:10.1016/0378-3782(90)90144-8

PMID:2076689

Abstract

The endogenous prostanoid production in human umbilical arteries from gestational stages between 192 and 290 days was investigated using an in vitro perfusion technique. The outflow concentrations of prostacyclin and thromboxane (measured as their stable metabolites 6-keto-PGF1 alpha and TXB2), PGE2 and PGF2 alpha were determined by RIA-methods. The production of all four prostanoids was found to increase with the duration of pregnancy. The formation of prostacyclin was always dominating, followed by PGE2, PGF2 alpha and thromboxane.

摘要

采用体外灌注技术研究了妊娠192至290天之间人脐动脉内源性前列腺素的产生情况。通过放射免疫分析法测定了前列环素和血栓素（以其稳定代谢产物6 - 酮 - PGF1α和TXB2衡量）、PGE2和PGF2α的流出浓度。发现所有四种前列腺素的产生均随妊娠时间的延长而增加。前列环素的形成始终占主导地位，其次是PGE2、PGF2α和血栓素。