Haugen G, Stray-Pedersen S, Bjøro K
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Gynecol Obstet Invest. 1995;39(1):8-10. doi: 10.1159/000292366.
The influence of phenazone on the production of prostacyclin and thromboxane in human umbilical arteries was investigated by in vitro perfusion. With perfusate concentrations ranging from 10(-7) to 10(-4) M a decrease in the formation of both prostanoids was observed. The inhibitory effect of phenazone on prostanoid formation was found to be equal to that of indomethacin.
通过体外灌注研究了非那宗对人脐动脉中前列环素和血栓素生成的影响。当灌注液浓度在10⁻⁷至10⁻⁴ M范围内时，观察到两种类前列腺素的生成均减少。发现非那宗对类前列腺素生成的抑制作用与吲哚美辛相当。
