Flandroy L, Galand P
J Cyclic Nucleotide Res. 1978 Apr;4(2):145-58.
The effect of estradiol-17beta, estriol, diethylstilbestrol and nafoxidine on rat uterine cGMP content was studied in relation with their respective estrogenic potency. Confirming previous results from Kuehl et al. (5), we observed a rise in uterine cGMP and a simultaneous decrease in cAMP content in treated animals. The reverse effect was obtained in the vagina after stimulation with estradiol or estriol. In the uterus, all compounds tested induced two main waves of cGMP increase corresponding to the two main phases of the estrogenic response i.e. the early fluid imbibition and the later period of true growth. No direct relationship could be established between the late rise in cGMP and true growth responses. A causal link between the first accumulation of uterine cGMP and the wet weight response in the early phase of estrogenic action is suggested by the comparison of time-course effects of the different compounds used on those two parameters.
研究了17β-雌二醇、雌三醇、己烯雌酚和萘福昔定对大鼠子宫环磷酸鸟苷（cGMP）含量的影响，并与其各自的雌激素活性相关联。证实了库尔等人（5）先前的结果，我们观察到在接受治疗的动物中子宫cGMP升高，同时环磷酸腺苷（cAMP）含量降低。在用雌二醇或雌三醇刺激后，阴道出现相反的效果。在子宫中，所有测试的化合物都诱导了cGMP增加的两个主要波峰，对应于雌激素反应的两个主要阶段，即早期的液体吸收和后期的真正生长阶段。cGMP的后期升高与真正的生长反应之间无法建立直接关系。通过比较不同化合物对这两个参数的时间进程效应，提示了子宫cGMP的首次积累与雌激素作用早期湿重反应之间的因果联系。
