[Effect of sex hormones on the content of cyclic nucleotides in the rat denervated uterus].

Estradiol dipropionate increased the amount of cGMP and to less extent that of cAMP in the uterine tissues of ovariectomized rats. The combined effect of estradiol and progesterone promoted rise only in the cAMP level. Surgical and pharmacological denervation of both sympathetic and parasympathetic nerve influences in uterus suppressed the effect of the above hormones. Thus, neuromediator processes play an essential role in realization of cAMP- and cGMP-dependent effects in the general program of the sex hormone action in the above organ.