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地钱(Ricciocarpos natans)成分及合成新月酸衍生物的杀螺特性

Molluscicidal properties of constituents from the liverwort Ricciocarpos natans and of synthetic lunularic acid derivatives.

作者信息

Wurzel G, Becker H, Eicher T, Tiefensee K

机构信息

Fachbereich 14.3 Pharmakognosie und Analytische Phytochemie, Universität des Saarlandes, Federal Republic of Germany.

出版信息

Planta Med. 1990 Oct;56(5):444-5. doi: 10.1055/s-2006-961007.

DOI:10.1055/s-2006-961007
PMID:2077548
Abstract

Five new sesquiterpenoids, three monocyclofarnesane, and two cuparane derivatives, isolated from the liverwort Ricciocarpos natans (L.) Corda have been tested against Biomphalaria glabrata, one of the snail vectors of schistosomiasis (bilharzia). Molluscicidal activity is exhibited by four of the sesquiterpenoids with an LC100 of 11 ppm of the most toxic compound. Lunularic acid, a common growth inhibitor of liverworts, and five of its synthetic derivatives have also been tested, and two derivatives were found to be highly active.

摘要

从苔类植物浮苔(Ricciocarpos natans (L.) Corda)中分离出的5种新倍半萜、3种单环法呢烷和2种蒈烷衍生物,已针对血吸虫病(裂体吸虫病)的蜗牛传播媒介之一光滑双脐螺(Biomphalaria glabrata)进行了测试。4种倍半萜表现出杀螺活性,毒性最强的化合物的LC100为11 ppm。苔类植物常见的生长抑制剂半月苔酸及其5种合成衍生物也进行了测试,发现其中2种衍生物具有高活性。

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