Ravelonjato B, Libot F, Ramiandrasoa F, Kunesch N, Gayral P, Poisson J
Laboratoire de Chimie des Substances Thérapeutiques Naturelles, Faculté de Pharmacie, Cedex, France.
Planta Med. 1992 Feb;58(1):51-5. doi: 10.1055/s-2006-961389.
Crude extracts of seeds, leaves and barks of four Madagascan Calophyllum species: C. inophyllum, C. recedens, C. chapelieri, and C. verticullatum, have been tested for molluscicidal activity against Biomphalaria glabrata. All seed extracts showed significant activity. The major constituents of the most active Calophyllum species were examined. Some related coumarinic derivatives were synthesized in order to improve the biological activity. Among the compounds prepared, 5,7-dihydroxy-6-(2-methylbutyryl)-4-phenyl-coumarin presented an interesting molluscicidal activity.
红厚壳、渐尖红厚壳、查氏红厚壳和轮生红厚壳的种子、叶子和树皮的粗提物进行了抗光滑双脐螺杀螺活性测试。所有种子提取物均表现出显著活性。对活性最高的红厚壳属植物的主要成分进行了研究。为提高生物活性合成了一些相关的香豆素衍生物。在所制备的化合物中，5,7-二羟基-6-(2-甲基丁酰基)-4-苯基香豆素表现出有趣的杀螺活性。
