Wilson S, Tafaro S T, Vieth R F
Ohio State University, Columbus.
Anesth Prog. 1990 Jan-Feb;37(1):11-5.
The purpose of this study was to evaluate the effect of a combination of a low dose of chloral hydrate and hydroxyzine on the frontalis muscle electromyogram in addition to other physiologic parameters in pediatric dental patients. A double blind, two-appointment cross-over design was used. Either a placebo or a combination of chloral hydrate and hydroxyzine was given to children during the first visit with the sequence of placebo/drug conditions being randomly determined. During the second visit, the children received that agent not given during the first visit. Baseline physiologic data was obtained at the beginning of each visit and the physiologic measures were again recorded during topical and local anesthesia administration, high-speed tooth preparation, and at the end of the dental appointment. The results indicated that the frontalis muscle activity and cardiovascular parameters were significantly affected by the drug and dental procedures. Oxygen saturation was least affected. The frontalis muscle appears to be a sensitive physiologic parameter to monitor during conscious sedation as an index of the amount of patient relaxation.
本研究的目的是评估低剂量水合氯醛与羟嗪联合使用对小儿牙科患者额肌肌电图以及其他生理参数的影响。采用双盲、两次就诊交叉设计。在首次就诊时,给儿童服用安慰剂或水合氯醛与羟嗪的组合,安慰剂/药物条件的顺序随机确定。在第二次就诊时,儿童服用首次就诊时未服用的药物。每次就诊开始时获取基线生理数据,并在局部和局部麻醉给药、高速牙体预备期间以及牙科就诊结束时再次记录生理指标。结果表明,药物和牙科操作对额肌活动和心血管参数有显著影响。氧饱和度受影响最小。在清醒镇静期间,额肌似乎是一个敏感的生理参数,可作为监测患者放松程度的指标。