Cecchini T, Cuppini R, Ciaroni S, Del Grande P
Istituto di Scienze Morfologiche, Università di Urbino, Italy.
Arch Ital Anat Embriol. 1990 Apr-Jun;95(2):155-65.
The regeneration of the sciatic nerve fibres was studied in both normal and vitamin E-deficient rats at 30 and 60 days after crush. The vitamin E is involved in one of the most important mechanisms of protection against peroxidation of plasma membrane lipids; the plasma membrane plays certainly a role in nerve regeneration. Both the diameter and the total number of myelinated nerve fibres was calculated at different times. The number of myelinated fibres in the undenervated deficient animals was lower than that found in the undenervated normals animals. Following the nerve crush, in normal animals after two months the number of myelinated fibres exceeded the number found in undenervated normal animals, whereas in the deficient rat nerves it was significantly lower than in the corresponding controls and moreover it did not even reach the number found in the nerves of undenervated deficient rats. Finally, the caliber distribution of myelinated fibres in undenervated and denervated deficient rats shows a relative percent increase in the number of greatest axons and a decrease in smaller axons. This result confirm the vitamin E to be an important factor of the normal process of nerve regeneration.
在正常大鼠和维生素E缺乏的大鼠中，于挤压伤后30天和60天对坐骨神经纤维的再生情况进行了研究。维生素E参与了防止质膜脂质过氧化的最重要机制之一；质膜在神经再生中肯定发挥着作用。在不同时间计算有髓神经纤维的直径和总数。未受神经损伤的缺乏维生素E动物中的有髓纤维数量低于未受神经损伤的正常动物。神经挤压伤后，在正常动物中，两个月后有髓纤维的数量超过了未受神经损伤的正常动物中的数量，而在缺乏维生素E的大鼠神经中，其数量显著低于相应的对照组，而且甚至未达到未受神经损伤的缺乏维生素E大鼠神经中的数量。最后，未受神经损伤和受神经损伤的缺乏维生素E大鼠中有髓纤维的口径分布显示，最大轴突数量的相对百分比增加，较小轴突数量减少。这一结果证实维生素E是神经再生正常过程中的一个重要因素。
