Cuppini R, Cecchini T, Cuppini C, Ciaroni S, Del Grande P
Istituto di Anatomia e Fisiologia Generale, Università di Urbino, Italy.
Muscle Nerve. 1990 Nov;13(11):1027-31. doi: 10.1002/mus.880131105.
A typical aspect of motoneuron plasticity is the sprouting which occurs during muscle reinnervation, resulting in a transitory multiple innervation of the muscle cells. In order to verify the effect of a decreased protection from free radical attack on the sprouting, the multiple innervation in the extensor digitorum longus muscle, following sciatic nerve crush and regeneration, was studied in vitamin E-deficient rats. Thus, the innervated end-plates and the end-plates with multiple innervation were studied with histochemical and electrophysiological techniques. The percentage of innervated end-plates was similar in both groups at 30 as well as at 60 days after nerve crush. Nevertheless, multiple innervation was found in a larger part of the muscle and it lasted longer in the deficient rats. This finding is discussed in relation to some of the major hypotheses of sprouting; it may be relevant in the treatment of some lesions of peripheral nerve.
运动神经元可塑性的一个典型特征是在肌肉重新神经支配过程中发生的轴突发芽，导致肌肉细胞出现短暂的多重神经支配。为了验证自由基攻击防护能力下降对轴突发芽的影响，在维生素E缺乏的大鼠中，研究了坐骨神经挤压和再生后趾长伸肌中的多重神经支配情况。因此，采用组织化学和电生理技术研究了有神经支配的终板和具有多重神经支配的终板。在神经挤压后30天和60天，两组中有神经支配的终板百分比相似。然而，在缺乏维生素E的大鼠中，肌肉中更大比例的区域发现了多重神经支配，且这种情况持续的时间更长。结合一些关于轴突发芽的主要假说对这一发现进行了讨论；它可能与某些周围神经损伤的治疗有关。
