Wood R, Chumbler F, Wiegand R D
Lipids. 1978 Apr;13(4):232-8. doi: 10.1007/BF02533661.
The effect of dietary cyclopropene fatty acids on the concentration of octadecenoate chain positional isomers in individual lipid classes of normal liver, host liver, and hepatoma 7288CTC has been determined. The data revealed the following: (a) Saturated and monoene fatty acid percentages of liver phosphatidylcholines and phosphatidylethanolamines were not affected, but the percentage of saturated fatty acids of the triglycerides and cholesteryl esters was increased while the monoene percentages decreased. (b) Oleate to vaccenate percentage ratios, previously shown to be characteristic of individual lipid classes, were completely disrupted. (c) Oleate concentrations of the two major liver phospholipids were elevated, and vaccenate levels were dramatically reduced. (d) Cyclopropene fatty acids appear to inhibit monoene elongation. (e) The elevated concentrations of oleate indicate that an alternate route of oleate biosynthesis must exist if the delta9 desaturation is inhibited by cyclopropene fatty acids as reported previously. (f) In contrast to liver, oleate and vaccenate concentrations in hepatoma were not affected by the dietary cyclopropene fatty acids.
已测定膳食环丙烯脂肪酸对正常肝脏、宿主肝脏及肝癌7288CTC个体脂质类别中十八碳烯酸链位置异构体浓度的影响。数据显示如下：(a)肝脏磷脂酰胆碱和磷脂酰乙醇胺的饱和脂肪酸和单烯脂肪酸百分比未受影响，但甘油三酯和胆固醇酯的饱和脂肪酸百分比增加，而单烯脂肪酸百分比降低。(b)先前显示为个体脂质类别特征的油酸与反式油酸百分比比值被完全打乱。(c)两种主要肝脏磷脂的油酸浓度升高，反式油酸水平显著降低。(d)环丙烯脂肪酸似乎抑制单烯脂肪酸延长。(e)油酸浓度升高表明，如果如先前报道的那样环丙烯脂肪酸抑制Δ9去饱和作用，那么必然存在油酸生物合成的替代途径。(f)与肝脏相反，肝癌中的油酸和反式油酸浓度不受膳食环丙烯脂肪酸的影响。
