Wood R, Zoeller A, Matocha M
Lipids. 1982 Nov;17(11):771-9. doi: 10.1007/BF02535353.
A large group of rats was transplanted with hepatoma 7288CTC and 4 animals were sacrificed at 3-day intervals for four weeks. Lipid class concentrations, fatty acid class compositions, and the distribution of cis octadecenoate positional isomers in the major lipid classes were determined for heart, liver and lung at each time period. The hearts of host animals decreased in dry weight as hepatoma growth progressed. At day 30, heart weights were less than two-thirds of initial weights. Lipid class concentrations changed in all three tissues: cholesterol and free fatty acids increased in liver; triglycerides and cholesterol decreased and then increased in heart; and cholesterol, triglycerides and PC decreased in lung as tumor growth progressed. Hexadecenoate percentages exhibited a progressive decrease in all the lipid classes of heart and liver. Although total octadecenoate percentages showed only minor changes, oleate concentrations generally increased and vaccenate levels decreased in heart and liver lipids as tumor growth progressed. Palmitoleate, precursor of vaccenate, exhibited decreased concentrations early that resulted in decreased vaccenate levels. Decreased palmitoleate concentrations suggest inhibition of the delta 9 desaturase system, but normal oleate concentrations complicate this interpretation. Most of the changes in the lipids were detectable 3-6 days after transplantation, indicating the hepatoma affects the lipid metabolism of the host animal early and well in advance of nutritional stresses.
将一大组大鼠移植肝癌7288CTC，每隔3天处死4只动物，持续4周。在每个时间段测定心脏、肝脏和肺中脂质类别浓度、脂肪酸类别组成以及主要脂质类别中顺式十八碳烯酸位置异构体的分布。随着肝癌生长，宿主动物心脏的干重下降。在第30天，心脏重量不到初始重量的三分之二。所有三种组织中的脂质类别浓度均发生变化：肝脏中胆固醇和游离脂肪酸增加；心脏中甘油三酯和胆固醇先下降后增加；随着肿瘤生长，肺中胆固醇、甘油三酯和磷脂酰胆碱减少。十六碳烯酸百分比在心脏和肝脏的所有脂质类别中均呈逐渐下降趋势。尽管总十八碳烯酸百分比仅显示出微小变化，但随着肿瘤生长，心脏和肝脏脂质中的油酸浓度总体上增加，而反式油酸水平下降。反式油酸的前体棕榈油酸早期浓度降低，导致反式油酸水平下降。棕榈油酸浓度降低表明δ9去饱和酶系统受到抑制，但正常的油酸浓度使这种解释变得复杂。脂质中的大多数变化在移植后3 - 6天即可检测到，这表明肝癌在营养应激之前就早早地影响了宿主动物的脂质代谢。
