Matocha M, Wood R
Lipids. 1980 Jun;15(6):421-7. doi: 10.1007/BF02534066.
The concentrations of the major neutral lipid and phospholipid classes in the plasma of rats bearing hepatoma 7288CTC were determined at various times after transplantation. The fatty acid composition of each lipid class was also analyzed quantitatively as tumor growth progressed. Generally, most lipid classes exhibited a slight decrease between the third and sixth day after transplantation, returned to near normal levels by the 15th day, increased dramatically and peaked between the 24th and 27th days before plummeting sharply. At peak concentrations, triglycerides were increased 5 times the normal levels, whereas cholesterol, cholesterly esters and phosphatidylcholines were increased 3-fold. The percentage of hexadecenoates decreased in all lipid classes as tumor growth progressed and generally, stearate levels increased. In addition to monounsaturated fatty acids, lysophosphatidylcholines and phosphatidylcholines showed relatively large decreases in the percentage of polyunsaturated fatty acids with increased tumor growth. These results indicate that hepatoma 7288CTC can cause perturbation of host animal plasma lipids in the early stages of growth which precedes the massive hyperlipidemia. The interpretation of these results suggests that the early changes in plasma lipids may result from alterations in the normal lipid metabolism of the host, and the hyperlipidemia that develops later may result from the mobilization of lipids to compensate for the altered metabolism.
在移植后不同时间测定了荷肝癌7288CTC大鼠血浆中主要中性脂质和磷脂类别的浓度。随着肿瘤生长的进展，还对每种脂质类别的脂肪酸组成进行了定量分析。一般来说，大多数脂质类别在移植后第三天到第六天之间略有下降，到第15天恢复到接近正常水平，然后急剧增加并在第24天到第27天之间达到峰值，随后又急剧下降。在浓度峰值时，甘油三酯增加到正常水平的5倍，而胆固醇、胆固醇酯和磷脂酰胆碱增加了3倍。随着肿瘤生长的进展，所有脂质类别中十六碳烯酸酯的百分比均下降，一般来说，硬脂酸水平升高。除了单不饱和脂肪酸外，溶血磷脂酰胆碱和磷脂酰胆碱随着肿瘤生长的增加，多不饱和脂肪酸的百分比也相对大幅下降。这些结果表明，肝癌7288CTC在生长早期可导致宿主动物血浆脂质紊乱，早于大量高脂血症出现。对这些结果的解释表明，血浆脂质的早期变化可能是由于宿主正常脂质代谢的改变，而后期出现的高脂血症可能是由于脂质动员以补偿代谢改变所致。
