Högstedt B, Bergmark E, Törnqvist M, Osterman-Golkar S
Department of Occupational Medicine, Central Hospital, Halmstad, Sweden.
Hereditas. 1990;113(2):133-8. doi: 10.1111/j.1601-5223.1990.tb00076.x.
Chromosomal aberrations and micronuclei in lymphocytes were measured in workers exposed to propylene oxide in a factory producing alkylated starch, and in workers exposed to ethylene oxide in connection with sterilization of medical equipment. Adduct levels in hemoglobin were determined as a measure of in vivo doses of the two compounds. The levels of hydroxypropylvaline in propylene oxide-exposed workers were correlated in estimated exposure doses. The levels of this adduct in the unexposed group were close to the detection limit of the method. The levels of hydroxyethylvaline, recorded in the propylene oxide-exposed group were consistent with earlier data on hemoglobin alkylation in occupationally unexposed subjects. The adduct measurements revealed increased levels of hydroxyethylvaline in the two subgroups of ethylene oxide-exposed workers, i.e., assemblers with a low and sterilizers with a high exposure. According to expectation the subgroups differed in adduct levels. The results of the cytogenetic study showed that the clastogenic potency of propylene oxide was lower than that of ethylene oxide, since the propylene oxide-exposed individuals had lower frequencies of micronuclei and chromosomal breaks compared to the assemblers despite a lower adduct level in the last group.
在一家生产烷基化淀粉的工厂中，对接触环氧丙烷的工人，以及在与医疗设备灭菌相关工作中接触环氧乙烷的工人，测量了淋巴细胞中的染色体畸变和微核。测定血红蛋白中的加合物水平，以衡量这两种化合物的体内剂量。环氧丙烷接触工人的羟丙基缬氨酸水平与估计的接触剂量相关。未接触组中这种加合物的水平接近该方法的检测限。环氧丙烷接触组中记录的羟乙基缬氨酸水平与职业未接触者血红蛋白烷基化的早期数据一致。加合物测量显示，环氧乙烷接触工人的两个亚组，即低接触的装配工和高接触的消毒工，羟乙基缬氨酸水平升高。正如预期的那样，这两个亚组的加合物水平不同。细胞遗传学研究结果表明，环氧丙烷的致断裂能力低于环氧乙烷，因为尽管最后一组的加合物水平较低，但与装配工相比，接触环氧丙烷的个体微核和染色体断裂的频率较低。
