自由基：它们对精子功能的有益和有害影响。
Free radicals: their beneficial and detrimental effects on sperm function.
作者信息
Kothari Shiva, Thompson Aaron, Agarwal Ashok, du Plessis Stefan S
机构信息
Center for Reproductive Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk A19.1, Cleveland, Ohio 44195, USA.
出版信息
Indian J Exp Biol. 2010 May;48(5):425-35.
Free radicals are molecules with one or more unpaired electron(s) commonly found in seminal plasma. Physiologically, free radicals control sperm maturation, capacitation and hyperactivation, the acrosome reaction, and sperm-oocyte fusion. Pathologically, free radicals induce lipid peroxidation, DNA damage and apoptosis of spermatozoa. The present review deals with both the beneficial and detrimental effects of free radicals on sperm function.
自由基是精液中常见的带有一个或多个未配对电子的分子。生理上，自由基控制精子成熟、获能和超活化、顶体反应以及精子-卵母细胞融合。病理上，自由基会诱导精子的脂质过氧化、DNA损伤和凋亡。本综述探讨了自由基对精子功能的有益和有害影响。
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