Becatti Matteo, Cito Gianmartin, Argento Flavia Rita, Fini Eleonora, Bettiol Alessandra, Borghi Serena, Mannucci Amanda, Fucci Rossella, Giachini Claudia, Picone Rita, Emmi Giacomo, Taddei Niccolò, Coccia Maria Elisabetta, Fiorillo Claudia
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, 50134 Firenze, Italy.
Department of Experimental and Clinical Medicine, University of Firenze, 50134 Firenze, Italy.
Antioxidants (Basel). 2023 Feb 14;12(2):479. doi: 10.3390/antiox12020479.
A large proportion of infertile men do not receive a clear diagnosis, being considered as idiopathic or unexplained cases due to infertility diagnosis based on standard semen parameters. Particularly in unexplained cases, the search for new indicators seems mandatory to provide specific information. In the etiopathogenesis of male infertility oxidative stress displays important roles by negatively affecting sperm quality and function. In this study, performed in a population of 34 idiopathic infertile men and in 52 age-matched controls, redox parameters were assessed in blood, leukocytes, spermatozoa, and seminal fluid and related to semen parameters. The main findings indicate that blood oxidative stress markers reflect seminal oxidative stress. Interestingly, blood leukocyte ROS production was significantly correlated to sperm ROS production and to semen parameters. Overall, these results suggest the potential employ of blood redox markers as a relevant and adjunctive tool for sperm quality evaluation aimed to preconception care.
很大一部分不育男性没有得到明确诊断，由于基于标准精液参数进行不育诊断，他们被视为特发性或不明原因的病例。特别是在不明原因的病例中，寻找新的指标似乎是提供具体信息的必要手段。在男性不育的病因发病机制中，氧化应激通过对精子质量和功能产生负面影响而发挥重要作用。在这项研究中，对34名特发性不育男性和52名年龄匹配的对照组进行了研究，评估了血液、白细胞、精子和精液中的氧化还原参数，并将其与精液参数相关联。主要研究结果表明，血液氧化应激标志物反映了精液氧化应激。有趣的是，血液白细胞ROS产生与精子ROS产生以及精液参数显著相关。总体而言，这些结果表明血液氧化还原标志物有可能作为一种相关的辅助工具，用于旨在孕前护理的精子质量评估。
