Pandurangan Muthuraman, Kim Doo Hwan
Department of Bioresources and Food Science, Konkuk University, Seoul, South Korea.
3 Biotech. 2016 Jun;6(1):94. doi: 10.1007/s13205-016-0411-0. Epub 2016 Mar 26.
Hypoglycemic effect of cyanobacteria has evaluated in the normal and streptozotocin-induced diabetic male albino rats as a mammalian model. Normal and streptozotocin-diabetic rats were orally administered cyanobacteria for 60 consecutive days, and their blood levels of glucose, insulin, C-peptide, lipid peroxidation, body weight and enzyme changes were determined using standard methods. Cyanobacteria administration reduced blood glucose level, and increased plasma insulin, C-peptide levels and restored the body weight. Cyanobacteria administration significantly reduced lipid peroxidation in the diabetic rats. Hexokinase enzyme activity was increased, whereas glucose-6-phosphatase enzyme activity decreased in streptozotocin-diabetic rats compared to their respective controls. Cyanobacteria administration caused significant renormalization of serum hepatic enzymes in streptozotocin-induced diabetic rats. In conclusion, cyanobacteria have a protective effect on anti-oxidant and anti-diabetic in streptozotocin-induced diabetic rats.
作为哺乳动物模型，已在正常和链脲佐菌素诱导的糖尿病雄性白化大鼠中评估了蓝藻的降血糖作用。正常大鼠和链脲佐菌素诱导的糖尿病大鼠连续60天口服蓝藻，使用标准方法测定其血糖、胰岛素、C肽、脂质过氧化、体重和酶变化的血液水平。给予蓝藻可降低血糖水平，增加血浆胰岛素、C肽水平并恢复体重。给予蓝藻可显著降低糖尿病大鼠的脂质过氧化。与各自的对照组相比，链脲佐菌素诱导的糖尿病大鼠中己糖激酶酶活性增加，而葡萄糖-6-磷酸酶酶活性降低。给予蓝藻可使链脲佐菌素诱导的糖尿病大鼠的血清肝酶显著恢复正常。总之，蓝藻对链脲佐菌素诱导的糖尿病大鼠具有抗氧化和抗糖尿病保护作用。
