Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9185, USA.
J Am Chem Soc. 2010 Sep 22;132(37):12829-31. doi: 10.1021/ja105563a.
The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.
描述了一种含有八个 GdDOTA 单元的聚赖氨酸树突的合成,该单元与一种已知对血管内皮生长因子受体 2(VEGFR2)具有高亲和力的肽二聚体相连。这种简单的低分子量系统的分子 r(1)弛豫率约为 48 mM(-1) s(-1),被证明可以增强体内生长的小鼠肿瘤的磁共振图像。