National Institute of Occupational Safety and Health, 6-21-6 Nagao, Tama-ku, Kawasaki 214-8585, Japan.
Occup Environ Med. 2011 Mar;68(3):231-4. doi: 10.1136/oem.2009.050419. Epub 2010 Aug 26.
Although occupational and environmental exposures to lead have been dramatically reduced in recent decades, adverse pregnancy outcomes have been observed at 'acceptable' levels of blood lead concentrations (≤ 10 μg/dl).
Blood samples were collected from 348 singleton pregnant women, aged 16-35 years, during the first trimester of pregnancy (8-12 weeks) for lead measurement by inductively coupled plasma-mass spectrometry. Subjects were followed up and divided into two groups (preterm and full-term deliveries) according to duration of gestation.
The average (range) and geometric means of blood lead levels were 3.8 (1.0-20.5) and 3.5 μg/dl, respectively. Blood lead level was significantly (p<0.05) higher in mothers who delivered preterm babies than in those who delivered full-term babies (mean±SD: 4.46±1.86 and 3.43±1.22 μg/dl, respectively). Logistic regression analysis demonstrated that a 1 unit increase in blood lead levels led to an increased risk of preterm birth (OR 1.41, 95% CI 1.08 to 1.84).
Adverse pregnancy outcomes may occur at blood lead concentrations below the current acceptable level.
尽管近几十年来职业和环境铅暴露已大幅减少，但在“可接受”血铅浓度（≤10μg/dl）水平仍观察到不良妊娠结局。
在妊娠早期（8-12 周）采集了 348 名 16-35 岁的单胎孕妇的血样，通过电感耦合等离子体质谱法测量血铅水平。根据妊娠持续时间，将这些孕妇分为两组（早产和足月分娩）。
血铅水平的平均值（范围）和几何平均值分别为 3.8（1.0-20.5）和 3.5μg/dl。与足月分娩的孕妇相比，早产孕妇的血铅水平显著升高（均值±标准差：4.46±1.86 和 3.43±1.22μg/dl）。Logistic 回归分析表明，血铅水平每增加 1 个单位，早产的风险就会增加（OR 1.41，95%CI 1.08-1.84）。
不良妊娠结局可能发生在当前可接受水平以下的血铅浓度。
