术后复发作为口腔发育异常性白斑恶变的一个相关因素。
Postoperative recurrence as an associated factor of malignant transformation of oral dysplastic leukoplakia.
作者信息
Yang Shih-Wei, Wu Chang-Jer, Lee Yun-Shien, Chen Tai-An, Tsai Chi-Neu
机构信息
Department of Otolaryngology, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China. sweeyang @ gmail.com
出版信息
ORL J Otorhinolaryngol Relat Spec. 2010;72(5):280-90. doi: 10.1159/000318874. Epub 2010 Aug 25.
PURPOSE
To evaluate the clinically associated factors of malignant transformation in patients who received laser surgery for oral dysplastic leukoplakia.
PROCEDURES
The clinicopathological data of patients receiving laser surgery for dysplastic leukoplakia from 2002 to 2008 and HPV genomic DNA extracted from paraffin-embedded specimens were analyzed statistically.
RESULTS
A total 114 patients, 90 males and 24 females with an average age of 49.7 ± 12.2 years were enrolled. The follow-up period ranged from 1.07 to 7.43 years (mean 3.4 ± 1.3 years). Thirteen cases had malignant transformation (11.4%). Multiple-focus lesions, non-homogeneous leukoplakia, high-grade dysplasia and recurrence after laser treatment were significant factors in univariate analysis. Multivariate analysis showed that recurrence (relative risk = 9.40) was the independent prognostic factor for malignant transformation.
CONCLUSIONS
Recurrence after laser treatment is an independent prognostic factor predicting malignant transformation of dysplastic oral leukoplakia.
目的
评估接受激光手术治疗口腔发育异常性白斑患者发生恶变的临床相关因素。
方法
对2002年至2008年接受激光手术治疗发育异常性白斑患者的临床病理资料以及从石蜡包埋标本中提取的HPV基因组DNA进行统计学分析。
结果
共纳入114例患者，其中男性90例，女性24例，平均年龄49.7±12.2岁。随访时间为1.07至7.43年（平均3.4±1.3年）。13例发生恶变（11.4%）。单因素分析显示，多灶性病变、非均质型白斑、高级别发育异常以及激光治疗后复发是显著因素。多因素分析表明，复发（相对风险=9.40）是恶变的独立预后因素。
结论
激光治疗后复发是预测发育异常性口腔白斑恶变的独立预后因素。
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