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青春期大鼠脑内髓鞘形成/少突胶质细胞相关基因表达的变化。

Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain.

机构信息

Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

出版信息

J Neural Transm (Vienna). 2010 Nov;117(11):1265-8. doi: 10.1007/s00702-010-0461-0. Epub 2010 Aug 27.

DOI:10.1007/s00702-010-0461-0
PMID:20798964
Abstract

Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.

摘要

采用微阵列和定量聚合酶链反应(qPCR)的方法研究了青春期前后大鼠前额叶皮层(PFC)中基因表达的年龄依赖性变化。与青春期前(PD35)相比，青春期后(PD56)大鼠 PFC 中分别有大约 127 个和 138 个基因增加和减少。功能分析表明，这些基因与衰老、细胞发育和神经精神障碍显著相关。qPCR 分析证实了与髓鞘形成相关的七个基因的下调。由于这些基因已在精神分裂症患者的大脑中被报道减少，因此本研究的结果表明，过度成熟的过程可能有助于精神疾病的发病机制。

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本文引用的文献

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A practical approach to RT-qPCR-Publishing data that conform to the MIQE guidelines.实时荧光定量 PCR（RT-qPCR）的实用方法-发表符合 MIQE 指南的数据。
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Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia.青春期前额叶皮层中的基因表达：对精神分裂症发病的影响。
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