Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 350 Freer Hall, 906 South Goodwin Ave., Urbana, IL 61801, USA.
Neurol Sci. 2011 Apr;32(2):255-62. doi: 10.1007/s10072-010-0396-0. Epub 2010 Aug 27.
Walking impairment is a ubiquitous feature of multiple sclerosis (MS) and the O(2) cost of walking might quantify this dysfunction in mild MS. This paper examined the difference in O(2) cost of walking between persons with MS who have mild disability and healthy controls and the correlation between the O(2) cost of walking and disability. Study 1 included 18 persons with mild MS and 18 controls and indicated that the O(2) cost of walking was significantly higher in MS than controls and that disability was significantly associated with the O(2) cost of slow, moderate, and fast treadmill walking. Study 2 included 24 persons with mild MS and indicated that disability was significantly correlated with O(2) cost of comfortable, fast, and slow over-ground walking. We provide evidence that the O(2) cost of walking is an indicator of walking dysfunction in mildly disabled persons with MS and should be considered in clinical research and practice.
步行障碍是多发性硬化症（MS）的普遍特征，步行的耗氧量（O2）可能可以量化轻度 MS 中的这种功能障碍。本文研究了轻度残疾的 MS 患者和健康对照组之间步行的耗氧量（O2）的差异，以及步行的耗氧量（O2）与残疾之间的相关性。研究 1 纳入了 18 名轻度 MS 患者和 18 名对照组，结果表明 MS 患者的步行耗氧量（O2）明显高于对照组，且残疾与慢、中、快跑步机步行的耗氧量（O2）显著相关。研究 2 纳入了 24 名轻度 MS 患者，结果表明残疾与舒适、快速和慢速地面步行的耗氧量（O2）显著相关。我们的研究结果表明，步行的耗氧量（O2）是轻度残疾 MS 患者步行功能障碍的一个指标，应该在临床研究和实践中加以考虑。
