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种族差异对唐氏综合征产前筛查参与度的影响:基于注册的研究。

Ethnic differences in participation in prenatal screening for Down syndrome: a register-based study.

机构信息

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

出版信息

Prenat Diagn. 2010 Oct;30(10):988-94. doi: 10.1002/pd.2603.

DOI:10.1002/pd.2603
PMID:20799374
Abstract

OBJECTIVE

To assess ethnic differences in participation in prenatal screening for Down syndrome in the Netherlands.

METHODS

Participation in prenatal screening was assessed for the period 1 January 2009 to 1 July 2009 in a defined postal code area in the southwest of the Netherlands. Data on ethnic origin, socio-economic background and age of participants in prenatal screening were obtained from the Medical Diagnostic Centre and the Department of Clinical Genetics. Population data were obtained from Statistics Netherlands. Logistic regression models were used to assess ethnic differences in participation, adjusted for socio-economic and age differences.

RESULTS

The overall participation in prenatal screening was 3865 out of 15 093 (26%). Participation was 28% among Dutch women, 15% among those from Turkish ethnic origin, 8% among those from North-African origin, 15% among those from Aruban/Antillean origin and 26% among women from Surinamese origin.

CONCLUSIONS

Compared to Dutch women, those from Turkish, North-African, Aruban/Antillean and other non-Western ethnic origin were less likely to participate in screening. It was unexpected that women from Surinamese origin equally participated. It should be further investigated to what extent participation and non-participation in these various ethnic groups was based on informed decision-making.

摘要

目的

评估荷兰唐氏综合征产前筛查中不同民族的参与差异。

方法

在荷兰西南部的一个特定邮政编码区域,评估了 2009 年 1 月 1 日至 2009 年 7 月 1 日期间的产前筛查参与情况。从医疗诊断中心和临床遗传学系获取了参与者的民族出身、社会经济背景和年龄等数据。人口数据来自荷兰统计局。使用逻辑回归模型,调整了社会经济和年龄差异,评估了参与方面的民族差异。

结果

共有 15093 名孕妇中有 3865 人(26%)接受了产前筛查。荷兰女性的参与率为 28%,土耳其裔女性为 15%,北非裔为 8%,阿鲁巴/安的列斯群岛裔为 15%,苏里南裔为 26%。

结论

与荷兰女性相比,土耳其、北非、阿鲁巴/安的列斯群岛和其他非西方民族的女性参与筛查的可能性较低。令人意外的是,苏里南裔女性的参与率相当高。应该进一步调查这些不同民族群体中参与和不参与的程度在多大程度上是基于知情决策。

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