相位表示法的氧合和脱氧血红蛋白浓度：近红外光谱测量的反相振荡意味着什么？
Phasor representation of oxy- and deoxyhemoglobin concentrations: what is the meaning of out-of-phase oscillations as measured by near-infrared spectroscopy?
出版信息
J Biomed Opt. 2010 Jul-Aug;15(4):040512. doi: 10.1117/1.3483466.
Abstract
We propose a phasor representation for oscillations at a given frequency (or relatively narrow frequency band) of hemoglobin concentrations in tissue, as well as hemoglobin concentrations measured by near-infrared spectroscopy. This representation provides a straightforward visualization of the phase relationships between oscillations of oxy-, deoxy-, and total hemoglobin concentrations ([HbO], [Hb], and [HbT], respectively). We observe that measured oscillations of [Hb] and [HbO] with a phase difference that is neither 0 nor pi must result from the combination of different physiological processes that are out of phase (or time shifted) with respect to each other. Finally, we propose the use of cross-correlation phasors to map phase relationships and correlation levels among hemoglobin oscillations measured at spatially distinct locations at a given frequency. Such a representation may find a natural application in the study of functional connectivity networks in the brain.
摘要
我们提出了一种在组织中血红蛋白浓度（或相对较窄的频带）的给定频率（或相对较窄的频带）下的振荡的phasor 表示，以及通过近红外光谱测量的血红蛋白浓度。这种表示提供了对氧合血红蛋白、脱氧血红蛋白和总血红蛋白浓度（分别为[HbO]、[Hb]和[HbT]）的振荡之间的相位关系的直观可视化。我们观察到，具有既不是 0 也不是 pi 的相位差的测量的[Hb]和[HbO]的振荡必须是由相对于彼此不同步（或时间偏移）的不同生理过程的组合引起的。最后，我们建议使用互相关phasor 在给定频率下在空间上不同位置测量的血红蛋白振荡之间映射相位关系和相关水平。这种表示形式可能在研究大脑中的功能连接网络中找到自然的应用。
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