Shocket I D, Golar K
Section of Gastroenterology and Nutrition, Boston VA Medical Center, MA 02130.
Nutr Rev. 1990 Aug;48(8):313-7. doi: 10.1111/j.1753-4887.1990.tb02969.x.
We present a case of the eosinophilia-myalgia syndrome in a patient taking large doses of L-tryptophan for sedation. He developed the now-classic findings of myalgias, skin changes, and marked eosinophilia. This syndrome was first recognized in late 1989, and epidemiologic studies have demonstrated an association of the clinical syndrome with ingestion of L-tryptophan. The mechanism of toxicity remains unknown. Casual use of L-tryptophan has been diminished by its rapid removal from the nutrition counter of health food stores.
我们报告一例服用大剂量L-色氨酸以助镇静的患者发生嗜酸性粒细胞增多性肌痛综合征。他出现了肌痛、皮肤改变和明显嗜酸性粒细胞增多这些如今已成为经典的表现。该综合征于1989年末首次被认识，流行病学研究已证实这种临床综合征与摄入L-色氨酸有关。毒性机制仍然不明。由于L-色氨酸迅速从健康食品店的营养柜台下架，其随意使用已减少。
