因摄入L-色氨酸导致的嗜酸性粒细胞增多性肌痛综合征。4例报告及马里兰州经验回顾。

Eosinophilia-myalgia syndrome due to L-tryptophan ingestion. Report of four cases and review of the Maryland experience.

作者信息

Roubenoff R, Coté T, Watson R, Levin M L, Hochberg M C

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

Arthritis Rheum. 1990 Jul;33(7):930-8. doi: 10.1002/art.1780330703.

DOI:10.1002/art.1780330703

PMID:2369429

Abstract

Eosinophilia-myalgia syndrome (EMS) is a recently described clinical entity that has been ascribed to taking over-the-counter preparations of the amino acid L-tryptophan. We describe 4 patients with EMS, 3 of whom presented with eosinophilic fasciitis, and we review the epidemiology of EMS reported in Maryland and discuss the possible pathophysiology of the disease. EMS should be considered in the differential diagnosis of severe myalgia, eosinophilia, and eosinophilic fasciitis.

摘要

嗜酸性粒细胞增多性肌痛综合征（EMS）是一种最近被描述的临床病症，它被认为与服用非处方的氨基酸L-色氨酸制剂有关。我们描述了4例EMS患者，其中3例表现为嗜酸性筋膜炎，并回顾了马里兰州报告的EMS流行病学情况，并讨论了该疾病可能的病理生理学。在严重肌痛、嗜酸性粒细胞增多和嗜酸性筋膜炎的鉴别诊断中应考虑EMS。