IBiTech-bioMMeda (Ghent University), Gent, Belgium.
Ultrasound Med Biol. 2010 Oct;36(10):1722-35. doi: 10.1016/j.ultrasmedbio.2010.06.021.
A two-dimensional (2-D) blood velocity estimator is presented combining speckle tracking (ST) and phase-shift estimation (PE) to measure lateral (vx) and axial (vz) velocities respectively. Estimator properties were assessed in a carotid bifurcation using ultrasound simulations based on computational fluid dynamics, allowing validation toward a ground truth. Simulation results were supported with in vivo data of a healthy carotid. ST and PE estimates were combined as: (1) vx from 2D-ST and vz from PE, (2) vx from 2D-ST and vz from PE with aliasing correction based on ST and (3) vz from PE and only lateral ST for vx. Regression analysis showed a 35% to 77% decrease in standard deviation for vz for PE compared with ST. Aliasing correction based on ST improved results but also introduced spurious artifacts. A marginal decrease in performance was observed when only tracking laterally. Further work will focus on in vivo trials in patients with carotid plaques.
本文提出了一种二维（2-D）血流速度估计方法，结合散斑跟踪（ST）和相移估计（PE）分别测量横向（vx）和轴向（vz）速度。该估计器的性能在基于计算流体动力学的颈动脉分叉的超声模拟中进行了评估，允许对真实情况进行验证。模拟结果得到了健康颈动脉的体内数据的支持。ST 和 PE 的估计值组合如下：（1）来自 2D-ST 的 vx 和来自 PE 的 vz，（2）来自 2D-ST 的 vx 和来自 PE 的 vz，具有基于 ST 的混叠校正，以及（3）来自 PE 的 vz 和仅用于 vx 的横向 ST。回归分析表明，与 ST 相比，PE 对 vz 的标准偏差降低了 35%至 77%。基于 ST 的混叠校正改善了结果，但也引入了虚假伪影。仅横向跟踪时，性能略有下降。进一步的工作将集中在颈动脉斑块患者的体内试验上。
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