肋骨后弱聚焦超声升温的理论与实验研究。
Theoretical and experimental study on temperature elevation behind ribs caused by weakly focused ultrasound.
机构信息
Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, People' Republic of China.
出版信息
Ultrasound Med Biol. 2010 Oct;36(10):1704-12. doi: 10.1016/j.ultrasmedbio.2010.07.018.
Temperature distribution in tissues behind ribs produced by weakly focused ultrasound had been calculated using Pennes bioheat equation and the validity of the theoretical model was experimentally confirmed in vitro using porcine live. We found that the position of the maximum temperature in tissue is strongly influenced by the distance between the transducer and ribs, while the gap between ribs is the determining factor for the maximum achievable temperature. Within the focal length, when the distance between the transducer and ribs increases, the maximum temperature increases and its position shifts away from the transducer. The rib width has little effect on the position of the maximum temperature but affects the achievable peak temperature. Our results provide useful information for treating liver cancers using ultrasound induced hyperthermia.
利用彭内斯生物传热方程计算了弱聚焦超声在肋骨后面组织中的温度分布，并通过猪活体实验验证了理论模型的有效性。我们发现，组织中最大温度的位置受换能器与肋骨之间距离的强烈影响，而肋骨之间的间隙是最大可达到温度的决定因素。在焦域范围内，当换能器与肋骨之间的距离增加时，最大温度增加，其位置从换能器处移开。肋骨宽度对最大温度的位置影响较小，但会影响可达到的峰值温度。我们的结果为使用超声诱导热疗治疗肝癌提供了有用的信息。
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