Department of Obstetrics and Gynecology, Institute for Fertility Preservation, New York Medical College-Westchester Medical Center, Valhalla, New York 10595, USA.
Fertil Steril. 2011 Feb;95(2):804.e7-10. doi: 10.1016/j.fertnstert.2010.07.1072.
To report the long-term follow-up of an experimental heterotopic ovarian transplantation with frozen-thawed ovarian tissue.
Long-term follow-up of an experimental surgery; case report.
Academic reproductive medicine center.
PATIENT(S): A 28-year-old cancer survivor with previous Hodgkin disease and relapse.
INTERVENTION(S): Laparoscopic oophorectomy for ovarian cryopreservation before preconditioning chemotherapy for hematologic stem cell transplantation. Ovarian tissue thawing and subcutaneous heterotopic ovarian transplantation in the lower abdominal wall 2½ years after the hematologic stem cell transplantation.
MAIN OUTCOME MEASURE(S): Resumption of ovarian function after transplantation, recovery of fertility, and pregnancy outcome.
RESULT(S): Follicle development was observed in the graft 2 months after transplantation, and a P value of 14 ng/mL indicated ovulation. The patient conceived spontaneously four times within 5 years and delivered three children. The in situ ovary remained atrophic but showed occasional follicle activity contemporaneously with the graft.
CONCLUSION(S): The mechanism behind spontaneous restoration of fertility with consecutive viable pregnancies after a heterotopic ovarian transplantation needs to be explored. Further laboratory and clinical research will be needed to explore the true origin of pregnancies after ovarian transplantations.
报告冷冻解冻卵巢组织异体异位移植的长期随访结果。
实验性手术的长期随访；病例报告。
学术生殖医学中心。
一位 28 岁的癌症幸存者，曾患有霍奇金病并复发。
在接受造血干细胞移植前预处理化疗前进行腹腔镜卵巢切除术以进行卵巢冷冻保存。造血干细胞移植后 2 年半进行卵巢组织解冻和皮下异位卵巢移植。
移植后卵巢功能恢复、生育能力恢复和妊娠结局。
移植后 2 个月观察到移植物中有卵泡发育，P 值为 14ng/mL 表明排卵。患者在 5 年内自然受孕 4 次并分娩了 3 个孩子。原位卵巢保持萎缩，但与移植物同时显示偶尔有卵泡活动。
需要探索异体异位卵巢移植后自发恢复生育能力并连续发生活产妊娠的机制。需要进一步的实验室和临床研究来探索卵巢移植后妊娠的真正来源。
