Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Unité de Recherche GYNE, Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Fertil Steril. 2011 Apr;95(5):1787.e1-4. doi: 10.1016/j.fertnstert.2010.11.041. Epub 2010 Dec 9.
To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue.
Case report.
Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels.
PATIENT(S): Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure.
INTERVENTION(S): Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation.
MAIN OUTCOME MEASURE(S): Restoration of ovarian activity.
RESULT(S): Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg.
CONCLUSION(S): Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.
报告一例冷冻卵巢组织原位移植后活产的病例。
病例报告。
布鲁塞尔圣吕克大学附属医院妇科。
患有转移性癌症的女性，于 2001 年在接受化疗和造血干细胞移植前冷冻保存卵巢组织，导致卵巢早衰。
冷冻保存 7 年后行卵巢皮质原位再植。
卵巢功能恢复情况。
再植后 3.5 个月观察到卵巢功能恢复，并在移植后 9 个月诊断为持续妊娠。患者分娩出一名健康婴儿，体重 2.830 千克。
本例患者是冷冻保存组织原位移植后第 13 例活产，但为转移性疾病治疗后首例。
