Turakulov Ia Kh, Dalimova S N
Probl Endokrinol (Mosk). 1990 Sep-Oct;36(5):71-4.
The purpose of the paper is to define the role of low molecular weight cytoplasmic proteins of peptide nature in the synthesis of young rat liver and brain mitochondrial proteins. The cytoplasmic modulator isolated from the hyperthyroid rat liver was shown to stimulate the synthesis of mitochondrial proteins of the hyperthyroid rat liver. A similar modulator from the hyperthyroid rat brain did not affect the protein-synthesizing apparatus of thyroidectomized rat liver mitochondria. In a cell-free system, containing brain mitochondria of rats with a different thyroid status, the cytoplasmic modulator failed to influence the incorporation of labeled amino acids in mitochondrial proteins. It is assumed that cytoplasmic low molecular weight modulators participate in a differentiated response of different organs to the action of thyroid hormones.
本文的目的是确定肽性质的低分子量细胞质蛋白在幼鼠肝脏和脑线粒体蛋白合成中的作用。从甲状腺功能亢进大鼠肝脏中分离出的细胞质调节剂被证明能刺激甲状腺功能亢进大鼠肝脏线粒体蛋白的合成。来自甲状腺功能亢进大鼠脑的类似调节剂对甲状腺切除大鼠肝脏线粒体的蛋白质合成装置没有影响。在含有不同甲状腺状态大鼠脑线粒体的无细胞系统中，细胞质调节剂未能影响标记氨基酸在线粒体蛋白中的掺入。据推测，细胞质低分子量调节剂参与了不同器官对甲状腺激素作用的分化反应。
