Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Neurobiol Aging. 2012 Jan;33(1):200.e23-31. doi: 10.1016/j.neurobiolaging.2010.07.010. Epub 2010 Aug 30.
The Rhesus monkey is a useful model for examining age-related as well as other neurological and developmental effects on the brain, because of the extensive neuroanatomical homology to the human brain, the reduced occurrence of neurological diseases such as Alzheimer's disease, and the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. In this study, cortical thickness measurements based on a cortical surface modeling technique were applied for the first time to investigate cortical thickness patterns in the rhesus monkey brain, and were used to evaluate regional age related effects across a wide range of ages. Age related effects were observed in several cortical areas, in particular in the somato-sensory and motor cortices, where a robust negative correlation of cortical thickness with age was observed, similar to that found in humans. In contrast, results for monkeys compared with humans show significant interspecies differences in cortical thickness patterns in the frontal and the inferior temporal regions.
恒河猴是研究大脑与年龄相关的以及其他神经发育影响的有用模型，因为它与人类大脑有广泛的神经解剖学同源性，神经退行性疾病（如阿尔茨海默病）的发生率较低，并且有可能获得相关的行为数据和死后组织进行组织学分析。在这项研究中，首次应用基于皮质表面建模技术的皮质厚度测量来研究恒河猴大脑的皮质厚度模式，并用于评估广泛年龄范围内的区域与年龄相关的影响。在几个皮质区域观察到了与年龄相关的影响，特别是在躯体感觉和运动皮质，在这些区域中观察到皮质厚度与年龄呈显著负相关，类似于在人类中发现的情况。相比之下，猴子与人类的比较结果显示，在额极和颞下回区域的皮质厚度模式存在显著的种间差异。
