糖苹果外果皮中的抗炎环肽。
Anti-inflammatory cyclopeptides from exocarps of sugar-apples.
机构信息
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
出版信息
Food Chem. 2014;152:23-8. doi: 10.1016/j.foodchem.2013.11.100. Epub 2013 Nov 28.
Two new cyclic peptides, fanlizhicyclopeptide A, cyclo(Pro(1)-Pro(2)-Tyr(3)-Leu(4)-Pro(5)-Gly(6)-Val(7)) (1), and fanlizhicyclopeptide B, cyclo(Pro(1)-Ile(2)-Tyr(3)-Ala(4)-Gly(5)) (2), were isolated along with six known kaurane diterpenoids and a known clovane sesquiterpene from the exocarps of sugar-apples, the fruit of Annona squamosa. Their structures were elucidated by ESI MS/MS experiments, 1D and 2D NMR data and chemical degradation. In the anti-inflammatory assay, both 1 and 2 showed in vitro inhibitory effects on the production of pro-inflammatory cytokines, TNF-α and IL-6, in LPS-stimulated RAW 264.7 macrophages.
两种新的环肽，番荔枝环肽 A，cyclo(Pro(1)-Pro(2)-Tyr(3)-Leu(4)-Pro(5)-Gly(6)-Val(7))(1)和番荔枝环肽 B，cyclo(Pro(1)-Ile(2)-Tyr(3)-Ala(4)-Gly(5))(2)，与 6 种已知的贝壳杉烷二萜和一种已知的石竹烷倍半萜，从番荔枝的外果皮中分离出来，番荔枝是番荔枝的果实。它们的结构通过 ESI MS/MS 实验、1D 和 2D NMR 数据和化学降解来阐明。在抗炎测定中，1 和 2 均在 LPS 刺激的 RAW 264.7 巨噬细胞中显示出体外抑制促炎细胞因子 TNF-α和 IL-6产生的作用。
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