Fakudze Nosipho Thembekile, Sarbadhikary Paromita, George Blassan P, Abrahamse Heidi
Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, P.O. Box 1701, Johannesburg 2028, South Africa.
Pharmaceuticals (Basel). 2023 Aug 8;16(8):1117. doi: 10.3390/ph16081117.
Africa is home to diverse medicinal plants that have been used for generations for the treatment of several different cancers and, presently, they are gaining interest from researchers as promising approaches to cancer treatment. This review aims to provide a comprehensive review of dietary and medicinal African fruits including their traditional uses, botanical description, ethnobotanical uses, bioactive phytochemical compositions, and anticancer properties investigated to date in vitro, in vivo, and in clinical studies. Data on recent updates concerning the traditional uses and anticancer properties of these fruits were collected from a myriad of available publications in electronic databases, such as Web of Science, PubMed, ScienceDirect, Scopus, SpringerLink, and Google Scholar. The results suggest that approximately 12 native or commercially grown African fruits belonging to different plant species, including , , , , , , , , , , and , have been reported for their potential as treatment options for the management of cancer. We further found that approximately eight different fruits from native plant species from Africa, namely, , , , , , and , have been widely used for the traditional treatment of different ailments but somehow failed to gain the interest of researchers for their use in anticancer research. In this review, we show the potential use of various fruits as anticancer agents, such as , , , , , , , , , , and ; unfortunately, not enough reported research data have been published to gain thorough mechanistic insights and clinical applications. Additionally, we discuss the possibility of the utilization of potential phytochemicals from fruits like and in anticancer research, as well as future directions.
非洲拥有多种药用植物，这些植物世代以来一直被用于治疗多种不同的癌症，目前，它们作为有前景的癌症治疗方法正引起研究人员的兴趣。本综述旨在全面回顾非洲的食用和药用水果，包括它们的传统用途、植物描述、民族植物学用途、生物活性植物化学成分，以及迄今为止在体外、体内和临床研究中所研究的抗癌特性。有关这些水果传统用途和抗癌特性的最新数据，是从电子数据库（如科学网、PubMed、ScienceDirect、Scopus、SpringerLink和谷歌学术）中大量可得的出版物中收集而来的。结果表明，大约有12种属于不同植物物种的非洲本土或商业种植水果，包括[此处列举水果名称，但原文未给出具体名称，无法准确翻译]，已被报道具有作为癌症治疗选择的潜力。我们还进一步发现，大约8种来自非洲本土植物物种的不同水果，即[此处列举水果名称，但原文未给出具体名称，无法准确翻译]，已被广泛用于传统治疗各种疾病，但不知为何未能引起研究人员对其在抗癌研究中应用的兴趣。在本综述中，我们展示了各种水果作为抗癌剂的潜在用途，例如[此处列举水果名称，但原文未给出具体名称，无法准确翻译]；遗憾的是，尚未发表足够多的研究数据以获得深入的作用机制见解和临床应用。此外，我们还讨论了在抗癌研究中利用来自[此处列举水果名称，但原文未给出具体名称，无法准确翻译]等水果的潜在植物化学物质的可能性，以及未来的研究方向。
