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在西班牙进行的国际哮喘和过敏研究(ISAAC)第三阶段中,阳光小时数和儿童哮喘患病率的变化。

Sunny hours and variations in the prevalence of asthma in schoolchildren according to the International Study of Asthma and Allergies (ISAAC) Phase III in Spain.

机构信息

Epidemiology Division, Centre of Public Health, Castellón, Spain.

出版信息

Int J Biometeorol. 2011 May;55(3):423-34. doi: 10.1007/s00484-010-0353-x. Epub 2010 Aug 28.

DOI:10.1007/s00484-010-0353-x
PMID:20803035
Abstract

The objective of this study was to estimate the relationship between the prevalence of asthma in schoolchildren aged 6-7 years and 13-14 years and the mean annual sunny hours (MASH) in Spain, and to explore predictive models for asthma prevalence. The prevalence of asthma was obtained from the International Study of Asthma and Allergies (ISAAC) Phase III 2002-2003, and climate and socio-economic variables from official sources. Nine centres were studied and a further four centres, two of which are in ISAAC, to test the predictive models. Logistic regression was used to estimate adjusted prevalence rates of asthma for each centre, and multiple regression models to study the effects of MASH and other meteorological and socio-economic variables. The adjusted prevalence rate of asthma decreased 0.6% [95% confidence interval (CI) 0.4-0.8%] for the 6-7 years group and 1.1% (95% CI 0.8-1.3%) for the 13-14 years group with an increase in the MASH of 100 h. Relative humidity was negatively associated with asthma in the older age group, and gross province product per capita (GPP) was positively associated with asthma in the younger age group. The predictive models, which included MASH, gender, relative humidity, and GPP, anticipated prevalence rates of asthma without significant differences between the levels observed and those expected in 9 of the 11 measurements carried out. The results indicate that sunny hours have a protective effect on the prevalence of asthma in schoolchildren.

摘要

本研究旨在估算西班牙 6-7 岁和 13-14 岁学龄儿童哮喘患病率与年均日照小时数(MASH)之间的关系,并探讨哮喘患病率的预测模型。哮喘患病率数据来自国际儿童哮喘和过敏研究(ISAAC)第三阶段 2002-2003 年的数据,气候和社会经济变量则来自官方来源。共研究了 9 个中心,并在其中的两个 ISAAC 中心进一步研究了另外 4 个中心,以测试预测模型。使用逻辑回归估算每个中心的哮喘校正患病率,并使用多元回归模型研究 MASH 及其他气象和社会经济变量的影响。MASH 每增加 100 小时,6-7 岁组哮喘的校正患病率下降 0.6%(95%置信区间:0.4-0.8%),13-14 岁组下降 1.1%(95%置信区间:0.8-1.3%)。相对湿度与年长组哮喘呈负相关,人均生产总值(GPP)与年幼组哮喘呈正相关。包括 MASH、性别、相对湿度和 GPP 在内的预测模型可以预测哮喘的流行率,而在进行的 11 次测量中的 9 次中,观察到的和预期的流行率之间没有显著差异。结果表明,日照时间对学龄儿童哮喘的患病率具有保护作用。

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Arch Bronconeumol. 2009 May;45(5):224-9. doi: 10.1016/j.arbres.2008.10.004. Epub 2009 Apr 16.