Department of Pathology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
Arch Iran Med. 2010 Sep;13(5):429-31.
Mycosis fungoides is the most common type of cutaneous malignant T cell lymphoma which primarily affects skin. However, extracutaneous manifestation may occur in advanced stages, mostly observed in postmortem studies. We present a case of mycosis fungoides that disseminated to the true vocal cord of a 48-year-old African American man who presented with hoarseness. Only two cases that have also demonstrated a rare involvement of the true vocal cord have been reported in the English literature. In both cases, mycosis fungoides infiltration of the true vocal cord was seen postmortem, along with visceral dissemination of mycosis fungoides. We herein describe a single extracutaneous manifestation of mycosis fungoides in the true vocal cord of a living patient with a 21-year diagnosis of mycosis fungoides. Vocal cord involvement by mycosis fungoides must be considered as one of the differential diagnoses in any mycosis fungoides patients who complain of persistent hoarseness. Awareness of this entity is clinically important due to the necessity of a different management.
蕈样肉芽肿是最常见的皮肤恶性 T 细胞淋巴瘤,主要累及皮肤。然而,在晚期可能会出现皮肤外表现,主要在尸检研究中观察到。我们报告了一例蕈样肉芽肿病例,该病例播散至一名 48 岁非裔美国男性的真声带,该男性以声音嘶哑为主要表现。仅在英文文献中报道了两例也罕见累及真声带的病例。在这两例病例中,尸检时均可见真声带蕈样肉芽肿浸润,同时伴有蕈样肉芽肿内脏播散。我们在此描述了一例蕈样肉芽肿的单一皮肤外表现,累及活存患者的真声带,该患者患有蕈样肉芽肿 21 年。任何患有持续性声音嘶哑的蕈样肉芽肿患者都应考虑到真声带受累作为鉴别诊断之一。由于需要不同的治疗,因此认识到这种疾病在临床上很重要。